PF-04457845
- русский язык имя
- английское имяPF-04457845
- CAS №1020315-31-4
- CBNumberCB62522724
- ФормулаC23H20F3N5O2
- мольный вес455.43
- номер MDLMFCD18782721
- файл Mol1020315-31-4.mol
химическое свойство
| Температура кипения | 687.0±55.0 °C(Predicted) |
| плотность | 1.389±0.06 g/cm3(Predicted) |
| температура хранения | room temp |
| растворимость | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml |
| пка | 12.72±0.20(Predicted) |
| форма | powder |
| цвет | white to beige |
| FDA UNII | H4C81M8YYW |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
PF-04457845 химические свойства, назначение, производство
Биохимия/физиол Действия
PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.PF-04457845 запасные части и сырье
сырьё
- Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1)
- Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester
- CarbaMic acid, N-3-pyridazinyl-, phenyl ester
- BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]-
- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)-
1of2
PF-04457845 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +undefined-21-51877795 | China | 32965 | 60 | |
| +1-631-485-4226 | United States | 19553 | 58 | |
| +1-781-999-5354 +1-00000000000 |
United States | 32161 | 58 | |
| 86-571-88216897,88216896 13588875226 |
CHINA | 6312 | 58 | |
| +1-708-310-1919 +1-13798911105 |
United States | 6391 | 58 | |
| United States | 38631 | 58 | ||
| +8618327326525 | China | 8467 | 58 | |
| +86-0533-2185556 +8617865335152 |
China | 10986 | 58 | |
| +86-852-30606658 | China | 43340 | 58 | |
| +86-18621343501; +undefined18621343501 |
China | 33338 | 58 |