GlyH-101
- русский язык имя
- английское имяGlyH-101
- CAS №328541-79-3
- CBNumberCB62446668
- ФормулаC19H15Br2N3O3
- мольный вес493.15
- номер MDLMFCD01532954
- файл Mol328541-79-3.mol
химическое свойство
Температура плавления | >300℃ (ethanol ) |
плотность | 1.73±0.1 g/cm3(Predicted) |
температура хранения | = -70C |
растворимость | DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM) DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM) |
форма | Yellow solid |
пка | 5.44±0.45(Predicted) |
цвет | Light yellow to yellow |
GlyH-101 химические свойства, назначение, производство
Описание
The cystic fibrosis (CF) gene encodes a cAMP-Общее описание
A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.GlyH-101 поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
---|---|---|---|---|
+undefined-21-51877795 | China | 32835 | 60 | |
+1-631-485-4226 | United States | 19553 | 58 | |
+86-0371-86658258 +8613203830695 |
China | 29821 | 58 | |
+1-781-999-5354 +1-00000000000 |
United States | 19892 | 58 | |
+1-708-310-1919 +1-13798911105 |
United States | 6393 | 58 | |
13417589054 | China | 11681 | 58 | |
+8618327326525 | China | 8474 | 58 | |
+1-+1(833)-552-7181 | United States | 57511 | 58 | |
571-89925085 | China | 131980 | 58 | |
China | 2923 | 55 |