Основные атрибуты  химическое свойство химические свойства, назначение, производство запасные части и сырье поставщик Обзор
 структурированное изображение

Ziprasidone

  • русский язык имя
  • английское имяZiprasidone
  • CAS №122883-93-6
  • CBNumberCB62131294
  • ФормулаC21H21ClN4OS
  • мольный вес412.943
  • EINECS602-903-0
  • номер MDLMFCD06795476
  • файл Mol122883-93-6.mol
химическое свойство
Температура плавления >300 °C
температура хранения Store at -20°C
растворимость Soluble in DMSO > 10 mM
форма Powder
Стабильность Hygroscopic
FDA UNII JAL53626GG
UNSPSC Code 41116107
NACRES NA.24

Ziprasidone химические свойства, назначение, производство

Описание

Both p.o. and i.m. formulations of ziprasidone were launched in Sweden for the treatment of schizophrenia and agitated psychoses. It is the sixth marketed atypical antipsychotic after clozapine, risperidone, olanzapine, sertindole and quetiapine. The synthesis of ziprasidone involves a novel one-step process for the preparation of 3-(1- piperazinyl)-1,2-benzisothiazole followed by coupling with a chlorooxindole fragment. Ziprasidone is a very potent 5-HT2A/D2 antagonist with a ratio of about 11 in favor of the serotonin receptor. It also shows very high 5-HT2c antagonistic activity, high 5-HT1A agonistic and 5-HT1D antagonistic activity, as well as moderate antagonism of α1 and H1 receptors and moderate norepinephrine and serotonin reuptake inhibition. Its complex binding profile for serotonin and dopamine receptors resulted during clinical trials in high antipsychotic efficacy with low extrapyramidal side effects and also in antidepressive action with low propensity for weight gain in opposition to other atypical and typical neuroleptics. An intramuscular formulation of ziprasidone was demonstrated to be superior to haloperidol, a conventional neuroleptic, for the short-term treatment of agitation in acutely psychotic patients. When administered orally in the fed state, this well-tolerated agent which strongly binds to plasma proteins shows a bioavailability of about 60% which is almost 2 fold greater than in the fasted state. It is transformed into 4 circulating major metabolites by different enzyme systems. The small QTc prolongation observed with ziprasidone was found to be comparable to other antipsychotic drugs and it is considered to be without significant risk.

Использование

Ziprasidone (Geodon, Zeldox) was the fifth atypical antipsychotic to gain FDA approval. In the United States, Ziprasidone is approved for the treatment of schizophrenia, and the intramuscular injection form of ziprasidone is approved for acute agitation i

Общее описание

A Certified Spiking Solution?; applicable to use in forensic drug analysis or calibrator preparation by LC/MS or GC/MS. Ziprasidone is sold under the trade names Geodon? and Zeldox for treatment of schizophrenia and bipolar disorder. Recent studies have suggested that Ziprasidone may increase the risk of Type II diabetes and hyperglycemia.

Ziprasidone поставщик

поставщик телефон страна номенклатура продукции благоприятные условия
008657128800458;
+8615858145714
China 7738 55
+86-0371-86658258
+8613203830695
China 29871 58
86-13657291602 CHINA 22963 58
+86-023-6139-8061
+86-86-13650506873
China 39894 58
8485655694 United States 63687 58
+8618523575427 China 49732 58
+1-781-999-5354
+1-00000000000
United States 32161 58
86-571-88216897,88216896
13588875226
CHINA 6312 58
+86-29-89586680
+86-15129568250
China 22787 58
571-88938639
+8617705817739
China 52849 58