ANTI-BRAIN DERIVED NEUROTROPHIC FACTOR

Использование

Anti-BDNF antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Общее описание

The antibody shows ~5% cross-reactivity with recombinant human β?NGF and recombinant rat β?NGF.

Биохимия/физиол Действия

Brain derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. Hence, variation in the BDNF gene expression alters these neurological functions. BDNF also plays a vital role in vascular function and participates in angiogenesis via the specific receptor tropomyosin-related kinase B (TrkB). It is involved in the pathogenesis of Alzheimer′s disease. ProBDNF interacts with p75 neurotrophin receptor, leading to long-term depression in the hippocampus.