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Трастузумаб
- английское имяTrastuzumab
- CAS №180288-69-1
- CBNumberCB61074602
- ФормулаC10H14N6O5
- мольный вес298.25536
- номер MDLMFCD03702625
- файл Mol180288-69-1.mol
химическое свойство
температура хранения | Store at -20°C |
форма | Solid |
цвет | White to light yellow |
Словарь онкологических терминов NCI | Herceptin |
FDA UNII | P188ANX8CK |
Словарь наркотиков NCI | Herceptin |
Банк данных об опасных веществах | 180288-69-1(Hazardous Substances Data) |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H360:Может отрицательно повлиять на способность к деторождению или на неродившегося ребенка.
Трастузумаб химические свойства, назначение, производство
Использование
Trastuzumab is used to treat breast cancer. It is effective against tumors that overexpress the HER2/neu protien. As part of chemotherapy regimen for adjuvant treatment of lymph-node positive, HER2/neu positive cancer.Показания
The introduction of herceptin (Trastuzumab) into clinical practice for the treatment of breast cancer marks a major advance in the use of monoclonal antibody cancer therapy. Herceptin is a humanized antibody directed against the HER-2 antigen that is overexpressed on the tumor cell surface in approximately 25% of breast cancer patients. HER-2/neu/erbB2 overexpression marks an aggressive estrogen receptor–negative form of breast cancer. Therefore, a therapeutic agent selective for this target is particularly valuable. Herceptin is administered by intravenous infusion and in conjunction with paclitaxel can extend survival in patients with HER-2/neu/erbB2 overexpressing metastatic breast cancer.Herceptin use is associated with infusion- related hypotension, flushing and bronchoconstriction, and skin rash but no bone marrow toxicity. Herceptin appears to sensitize patients to cardiotoxicity, an important concern in patients also receiving doxorubicin.использованная литература
[1] Hamid Maadi. “Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma.” Cancers (2021).Трастузумаб поставщик
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