1400W

Химические свойства

White Solid

Использование

1400W selectively inhibits inducible nitric oxide synthase. W 1400 has been implicated to prevent Doxorubicin and Trastuzumab induced cardiotoxicity.

Биологическая активность

Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K d = 7 nM). Selective over nNOS and eNOS (K i values are 2 and 50 μ M respectively). Cell-permeable and active in vivo .