ACEPROMAZINE MALEATE

Описание

Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine , and a dopamine receptor antagonist. It also binds to muscarinic receptors in rat brain (IC₅₀ = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine (; IC₅₀ = 840 nM). Acepromazine inhibits morphine-induced vomiting in dogs. It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED₅₀s = 0.98, 3.1, and 17 mg/kg, respectively). Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.

Химические свойства

Yellow Crystalline Solid

Использование

Acepromazine maleate has been used:

• as a component of anesthesia cocktail to test its effects on behavioral changes in rats
• as a component of anesthesia cocktail to study its effects on lung resistance of rats
• as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells

Профиль безопасности

Poison by ingestion, subcutaneous,and intravenous routes. When heated to decomposition itemits highly toxic fumes of NOx and SOx.