Метил ацетоацета

Химические свойства

Colorless, clear liquid

Использование

Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

Методы производства

Methyl acetoacetate is produced by a reaction of methyl acetate with sodium methoxide.

прикладной

Methyl acetoacetate (MAA) has been used for the following applications:
As a chemical reagent for organic synthesis and as a solvent for cellulose ethers;
As a chemical intermediate for organic compounds, used for the synthesis of nifedipine;
As a food additive, used as an amine protectant for synthetic sweeteners;
As a pharmaceutical raw material, used in the manufacture of antibiotics.

Общее описание

A clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air.

Реакции воздуха и воды

Very slightly soluble in water.

Профиль реактивности

Methyl acetoacetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides

Опасность

Toxic by ingestion and inhalation.

Угроза здоровью

May be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation.

Профиль безопасности

Moderately toxic by ingestion. A skin and severe eye irritant. Combustible when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Канцерогенность

Not listed by ACGIH, IARC, NTP, or California Proposition 65.