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1,1,1,2,3,3,3-Heptafluoropropane
- русский язык имя
- английское имя1,1,1,2,3,3,3-Heptafluoropropane
- CAS №431-89-0
- CBNumberCB4692270
- ФормулаC3HF7
- мольный вес170.03
- EINECS207-079-2
- номер MDLMFCD00043834
- файл Mol431-89-0.mol
химическое свойство
Температура плавления | -126.8°C |
Температура кипения | -16.4°C |
плотность | 1,409 g/cm3 |
показатель преломления | 1.2747 (estimate) |
растворимость | Soluble 1 in 1725 parts of water at 20°C. |
Стабильность | Stable. Incompatible with strong oxidizing agents, alkali metals |
LogP | 1.610 (est) |
Справочник по базе данных CAS | 431-89-0(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | R40P36GDK6 |
Справочник по химии NIST | 1,1,1,2,3,3,3-Heptafluoropropane(431-89-0) |
Система регистрации веществ EPA | HFC-227ea (431-89-0) |
Коды опасности | Xi | |||||||||
Заявления о безопасности | 23-38 | |||||||||
РИДАДР | 3296 | |||||||||
Примечание об опасности | Irritant | |||||||||
Класс опасности | 2.2 | |||||||||
кода HS | 2903460010 | |||||||||
Банк данных об опасных веществах | 431-89-0(Hazardous Substances Data) | |||||||||
Токсичность | mouse,LC,inhalation,> 7200gm/m3/4H (7200000mg/m3),BEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: DYSPNEA,Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996. | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H319:При попадании в глаза вызывает выраженное раздражение.
H335:Может вызывать раздражение верхних дыхательных путей.
H280:Газ под давлением. Баллоны (емкости) могут взрываться при нагревании.
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оператор предупредительных мер
P260:Не вдыхать газ/ пары/ пыль/ аэрозоли/ дым/ туман.
P271:Использовать только на открытом воздухе или в хорошо вентилируемом помещении.
P280:Использовать перчатки/ средства защиты глаз/ лица.
1,1,1,2,3,3,3-Heptafluoropropane химические свойства, назначение, производство
Химические свойства
Heptafluoropropane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. The gas in high concentration has a faint etherlike odor. Heptafluoropropane is noncorrosive, nonirritating, and nonflammable.Использование
HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems; as a fire suppressant; and for pharmaceutical aerosols and metered-dose inhalers.Фармацевтические приложения
Heptafluoropropane is classified as a hydrofluorocarbon (HFC) aerosol propellant since the molecule consists only of carbon, fluorine, and hydrogen atoms. It does not contain any chlorine and consequently does not affect the ozone layer, nor does it have an effect upon global warming. It is therefore considered as an alternative propellant to CFCs for metered-dose inhalers (MDIs). While some of its physical and chemical properties are known, little has been published in regard to its use as a replacement for CFCs in MDIs.The vapor pressure of heptafluoropropane is somewhat lower than that of tetrafluoroethane and dichlorodifluoromethane but considerably higher than the vapor pressure used to formulate most MDIs.
When heptafluoropropane is used for pharmaceutical aerosols and MDIs, the pharmaceutical grade must be specified. Industrial grades may not be suitable due to their impurity profile. Similarly to tetrafluoroethane, heptafluoropropane is not a good solvent for medicinal agents or for the commonly used surfactants and dispersing agents used in the formulation of MDIs.
There are several MDIs formulated with this propellant worldwide that contain a steroid as the active ingredient.
Безопасность
Heptafluoropropane is used as a fire extinguisher and is applicable as a non-CFC propellant in various metered-dose inhalers. Heptafluoropropane is regarded as nontoxic and nonirritating when used as directed. No acute or chronic hazard is present when it is used normally. Inhaling high concentrations of heptafluoropropane vapors can be harmful and is similar to inhaling vapors of other propellants. Deliberate inhalation of vapors of heptafluoropropane can be dangerous and may cause death. The same labeling required of CFC aerosols would be required for those containing heptafluoropropane as a propellant (except for the EPA requirement).хранилище
Heptafluoropropane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.