Н-Tyr-Leu-Tyr-Gln-ГТО-Leu-Gly-Ala-Pro-Val-PRO-TYR-PRO-Asp-Pro-Leu-ГЛК-Pro-Arg-Arg-ГЛК-Val-Cys-GLA- Leu-Asn-PRO-ASP-Cys-Asp-Glu-НОУ-АЛК-Asp-His-Ile-Gly-Phe-Gln-Glu-АЛК-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val- ОЙ

Описание

Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget''s disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in women. In vitro, osteocalcin induces chemotaxis of MDA-MB-231 breast cancer cells, human peripheral blood monocytes, and rat osteosarcoma cells with osteoblast-like characteristics. It is also expressed by vascular smooth muscle cells (VSMCs) displaying an osteoblast-like phenotype and has been positively associated with calcification of aortic tissue and heart valves in humans.