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![Н-Tyr-Leu-Tyr-Gln-ГТО-Leu-Gly-Ala-Pro-Val-PRO-TYR-PRO-Asp-Pro-Leu-ГЛК-Pro-Arg-Arg-ГЛК-Val-Cys-GLA- Leu-Asn-PRO-ASP-Cys-Asp-Glu-НОУ-АЛК-Asp-His-Ile-Gly-Phe-Gln-Glu-АЛК-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val- ОЙ структурированное изображение](/CAS/GIF/136461-80-8.gif)
Н-Tyr-Leu-Tyr-Gln-ГТО-Leu-Gly-Ala-Pro-Val-PRO-TYR-PRO-Asp-Pro-Leu-ГЛК-Pro-Arg-Arg-ГЛК-Val-Cys-GLA- Leu-Asn-PRO-ASP-Cys-Asp-Glu-НОУ-АЛК-Asp-His-Ile-Gly-Phe-Gln-Glu-АЛК-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val- ОЙ
- английское имяH-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH
- CAS №136461-80-8
- CBNumberCB4370884
- ФормулаC269H381N67O82S2
- мольный вес5929.43
- номер MDLMFCD00147801
- файл Mol136461-80-8.mol
химическое свойство
температура хранения | -20°C |
растворимость | Formic Acid: 1 mg/ml |
форма | solid |
FDA UNII | C5F7I87K3N |
Н-Tyr-Leu-Tyr-Gln-ГТО-Leu-Gly-Ala-Pro-Val-PRO-TYR-PRO-Asp-Pro-Leu-ГЛК-Pro-Arg-Arg-ГЛК-Val-Cys-GLA- Leu-Asn-PRO-ASP-Cys-Asp-Glu-НОУ-АЛК-Asp-His-Ile-Gly-Phe-Gln-Glu-АЛК-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val- ОЙ химические свойства, назначение, производство
Описание
Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget''s disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in women. In vitro, osteocalcin induces chemotaxis of MDA-MB-231 breast cancer cells, human peripheral blood monocytes, and rat osteosarcoma cells with osteoblast-like characteristics. It is also expressed by vascular smooth muscle cells (VSMCs) displaying an osteoblast-like phenotype and has been positively associated with calcification of aortic tissue and heart valves in humans.Н-Tyr-Leu-Tyr-Gln-ГТО-Leu-Gly-Ala-Pro-Val-PRO-TYR-PRO-Asp-Pro-Leu-ГЛК-Pro-Arg-Arg-ГЛК-Val-Cys-GLA- Leu-Asn-PRO-ASP-Cys-Asp-Glu-НОУ-АЛК-Asp-His-Ile-Gly-Phe-Gln-Glu-АЛК-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val- ОЙ поставщик
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