EC330
- русский язык имя
- английское имяEC330
- CAS №2016795-77-8
- CBNumberCB43171691
- ФормулаC30H32F2O2
- мольный вес462.57
- файл Mol2016795-77-8.mol
химическое свойство
Температура кипения | 623.4±55.0 °C(Predicted) |
плотность | 1.26±0.1 g/cm3(Predicted) |
температура хранения | Store at -20°C |
растворимость | DMSO : 20 mg/mL (43.24 mM) |
форма | Solid |
пка | 12.90±0.60(Predicted) |
цвет | White to gray |
EC330 химические свойства, назначение, производство
Описание
EC330 is used as potential LIF inhibitors. The remaining EC330-like inhibitors include EC357, and EC363. They were designed based on the structure–activity relationship (SAR) studies on human breast cancer MCF7 cells with LIF overexpression. The SAR established through this screening includes following criteria: (i) the steroidal skeleton of the molecule is an antiprogestin, (ii) the molecule has the specific 17α-difluoro acetylenic moiety, and (iii) nonpolar substituents at position 11 are preferred over polar substituents. EC330, EC357, and EC363 have all these features. EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.[1].EC330 поставщик
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