(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
- русский язык имя
- английское имя(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
- CAS №1523404-29-6
- CBNumberCB42742380
- ФормулаC18H25F3N4O3
- мольный вес402.41
- номер MDLMFCD28411355
- файл Mol1523404-29-6.mol
химическое свойство
| Температура кипения | 466.4±55.0 °C(Predicted) |
| плотность | 1.40±0.1 g/cm3(Predicted) |
| температура хранения | Sealed in dry,Room Temperature |
| растворимость | Ethanol: 50 mg/mL (124.25 mM) |
| пка | 0.08±0.40(Predicted) |
| форма | Solid |
| цвет | White to off-white |
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one химические свойства, назначение, производство
Использование
(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one, is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively.(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one запасные части и сырье
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one поставщик
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