Терутробан

Описание

The lipid mediator thromboxane A₂ (TXA₂) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA₂ are mediated by its specific G protein coupled-receptor, referred to as the TXA₂ receptor or TP. S18886 is an orally active, long-acting antagonist of the TP receptor with an IC₅₀ value of 16.4 nM. It inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis. S18886 is the active isomer of the potent TP receptor antagonist, S18204. Antagonists of TP receptors have advantages over aspirin as they not only block the effect of TXA₂ on platelets, but also inhibit other ligands such as prostaglandin endoperoxides and isoprostanes.

Использование

Terutroban functions as an anti-platelets therapies for patients with ischemic stroke or transient ischemic attack. Also used in the research process of anti-coagulant drugs in preventing and controlling cerebral stroke.