соединение 80-53
- английское имяBulaquine
- CAS №79781-00-3
- CBNumberCB41344929
- ФормулаC21H27N3O3
- мольный вес369.46
- номер MDLMFCD00890219
- файл Mol79781-00-3.mol
химическое свойство
| Температура кипения | 616.7±55.0 °C(Predicted) |
| плотность | 1?+-.0.06 g/cm3(Predicted) |
| пка | 5.60±0.20(Predicted) |
| FDA UNII | TSQ6U39Q3G |
соединение 80-53 химические свойства, назначение, производство
Описание
Bulaquine is a derivative of primaquine that was introduced in India in combination with chloroquine as a treatment against malaria. The compound is prepared by condensation of primaquine with 3-acetyl-y-butyrolactone in presence of a catalytic amount of base. Bulaquine kills the latent tissue stage (hypnozoites) of the parasite Plasmodium vivax accumulated in the liver and responsible for relapses. Its efficient anti-relapse activity was demonstrated against sporozoite induced Plasmodium cynomolgi infection in rhesus monkey. Bulaquine is safer than primaquine, the preceding candidate against malaria relapse. Although it is stable at pH 7-8, bulaquine is hydrolyzed to primaquine under acidic conditions.Создатель
CDRI (India)Имя бренда
Aablaquinсоединение 80-53 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +1-781-999-5354 | United States | 19973 | 58 | |
| 18080489829 | China | 9209 | 58 | |
| 15002134094 | China | 19696 | 58 |