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2-пиридин-3-илпиперидин
- английское имя(-)-ANABASINE
- CAS №13078-04-1
- CBNumberCB4100643
- ФормулаC10H14N2
- мольный вес162.23
- EINECS621-972-8
- номер MDLMFCD00871391
- файл Mol13078-04-1.mol
химическое свойство
Температура плавления | 9 °C |
Температура кипения | 270 °C |
плотность | 1.05 g/mL at 25 °C(lit.) |
показатель преломления | 1.5440 |
Fp | 93 °C |
температура хранения | Keep in dark place,Inert atmosphere,2-8°C |
растворимость | H2O: 10 mg/mL |
пка | 8.98±0.10(Predicted) |
форма | liquid |
цвет | colorless to yellow |
Мерк | 14,619 |
БРН | 82639 |
ИнЧИКей | MTXSIJUGVMTTMU-UHFFFAOYSA-N |
LogP | 0.852 (est) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | LMS11II2LO |
Коды опасности | T,Xn | |||||||||
Заявления о рисках | 23/24/25-36/37/38-25-20/21/22-51/53-27/28 | |||||||||
Заявления о безопасности | 36/37/39-45-26-36-57-27/28-23-20 | |||||||||
РИДАДР | UN 3140 6.1/PG 2 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | BV4375000 | |||||||||
Примечание об опасности | Toxic | |||||||||
Класс опасности | 6.1 | |||||||||
Группа упаковки | I | |||||||||
кода HS | 29339900 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H301:Токсично при проглатывании.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P310:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P405:Хранить в недоступном для посторонних месте.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
2-пиридин-3-илпиперидин химические свойства, назначение, производство
Описание
Anatabine is an alkaloid found in the root, fibrous roots, or bark of Alangium chinense (Lour) Harms. The herb was recorded in “Jianyi Bencao,” “Bencao Gangmu Shiyi,” and “Zhi Wu Ming Shi Tu Kao.” Alangium chinense is widely distributed in the east and south of China. It is also called “Bailongxu” in Shaanxi, Yunnan, and Guizhou provinces, “Baijintiao” in Guangxi province, and “Bajiaowutong,” “Bajiaojinpan,” or “Laolongxu” in Jiangxi and Hubei provinces. This plant is commonly used as a traditional Chinese medicine. The Alangium species includes more than 30 plants which are distributed in Asia, Oceania, and Africa. Nine of these plants are distributed in China. The root and the stem parts of Alangium plants are toxic.Химические свойства
Colourless OilФизические свойства
Appearance: Colorless to yellow liquid. Solubility: Soluble in water and common organic solvents. Boiling point: 110?°C. Refractive index: 1.5418. Density: 1.0516?g cm?3.История
Alangium chinense contains alkaloids, sugars, saponins, steroids, triterpenes, anthraquinones and their glycosides, and other ingredients. In 1974, dl-anabasine was isolated from the fibrous roots of Alangium chinense . Four isoquinoline alkaloids including two new alkaloids (?)-10-O-dimethyl-eugenol base and 10-O-dimethyl-eugenol base were isolated. P-amyrin acetate, triacontanol, and β-sitosterol were then found in its leaves . Seven glycosides were isolated from the water-soluble fraction of dried leaves of Alangium chinense, and eight glycosides were also isolated from the n-butanol soluble part . Three new lignincompounds including 2-O-(β-apio-furanosyl)-β-glucoside, E ferulic acid ester, and Z ferulic acid ester were extracted from Alangium chinense, and their structures were determined. Nakamoto et?al. extracted 7-O-acetylmaleic acid from Alangium chinense and determined the structure. There are also long-chain fatty acids and short-chain alkanes in Alangium chinense leaves. The volatile oil was then analyzed, and 59 components are identified by GC-MS.?The total alkaloid content in the Alangium chinense was found to be fibrous root > fine root > coarse root > branch wood > leaf.Использование
A nicotinic receptor agonistОпределение
ChEBI: A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.Общее описание
Anabasine inhibited androstenedione conversion to estrogen in a dose-dependent manner.Фармаколо?гия
Alangium plants have wide pharmacological effects including muscle relaxation, central inhibition, anticancer, antibacterial, and so on. The “Jisong-II” injection has presynaptic and postsynaptic effects on the neuromuscular junction, and it acts as noncompetitive muscular relaxant . In 1979, the respiratory suppression experiments showed that Alangium chinense is a central nervous system depressant . The extract of Alangium chinense significantly inhibits the growth of P388 lymphoblastic leukemia and Gardner lymphosarcoma in mice, but it has no effect on Gross virus-induced leukemia, Warner myelomonocytic leukemia, and B16 melanoma . Another study reported that the anabasine could excite respiratory similar to nicotine and lobeline. Anabasine also induces high blood pressure and bradycardia. The components in the Alangium chinense extract can bind to the M, 5-HT and dopamine receptors indicating that Alangium chinense affects the central nervous system.Клиническое использование
The Alangium chinense was used for treating rheumatoid arthritis.2-пиридин-3-илпиперидин запасные части и сырье
запасной предмет
2-пиридин-3-илпиперидин поставщик
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