Muscarinic toxin 1

Биологические функции

Muscarinic toxin 1 has non-competitive interactions with adrenergic and muscarinic receptors. Binds to alpha-2b (ADRA2B) (IC50=2.3 nM), alpha-1a (ADRA1A), alpha-1b (ADRA1B) and alpha-2c (ADRA2C) adrenergic receptors. Reversibly binds to the M1 (CHRM1) muscarinic acetylcholine receptor, probably through interaction with the orthosteric site. Also has slightly weaker effects on M3 (CHRM3) and M4 (CHRM4) receptors. The order of potency is ADRA2B>>CHRM1>ADRA1A>ADRA1B>ADRA2C/CHRM4 (PubMed:24793485).