AMG 925
- русский язык имя
- английское имяAMG 925
- CAS №1401033-86-0
- CBNumberCB32685918
- ФормулаC26H29N7O2
- мольный вес471.55
- номер MDLMFCD28155269
- файл Mol1401033-86-0.mol
химическое свойство
| Температура кипения | 712.3±70.0 °C(Predicted) |
| плотность | 1.48±0.1 g/cm3(Predicted) |
| температура хранения | Store at -20°C |
| растворимость | insoluble in DMSO; insoluble in H2O; insoluble in EtOH |
| форма | solid |
| пка | 13.41±0.10(Predicted) |
| цвет | Light yellow to yellow |
| FDA UNII | RB6Y814V4I |
AMG 925 химические свойства, назначение, производство
Описание
AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.AMG 925 запасные части и сырье
сырьё
- 2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)-
- 1401033-82-6
- 2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)-
- 9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)-
- 2-methylpropan-2-yl 2-({9-[(1r,4r)-4-methylcyclohexyl]pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine-6-carboxylate
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AMG 925 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +1-631-485-4226 | United States | 19553 | 58 | |
| +1-781-999-5354 +1-00000000000 |
United States | 32161 | 58 | |
| +1-708-310-1919 +1-13798911105 |
United States | 6391 | 58 | |
| United States | 38631 | 58 | ||
| +1-+1(833)-552-7181 | United States | 57505 | 58 | |
| 571-89925085 | China | 131957 | 58 | |
| 17702719238 17702719238 |
China | 1005 | 64 | |
| 0411-62910999 13889544652 |
China | 4727 | 58 | |
| 021-58170097 | China | 9478 | 58 | |
| 021-58950125 | China | 7552 | 61 |