Гуанин

Химические свойства

white to light yellow crystal powder

История

Guanine is one of the two purines comprising the five nucleic acid bases. Much of the information regarding the general role of nucleic acid bases is covered in Adenine and Cytosine. Guanine gets its name from guano, from which it was first isolated in the 1840s. Albrecht Kossel (1853 1927) determined that guanine (as well as adenine, cytosine, thymine and uracil) was a component of nucleic acid in the last two decades of the 19th century. Similar to adenine, guanine combines with ribose to form a nucleoside. The nucleoside produced is guanosine, which in turn combines with one to three phosphoryls to yield the nucleotides guanosine monophosphate (GMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP), respectively. Guanine nucleotides play an important role in metabolism including the conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) and carbohydrate metabolism.

Использование

Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.

Определение

ChEBI: Guanine is a 2-aminopurine carrying a 6-oxo substituent. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purine nucleobase, an oxopurine and a member of 2-aminopurines. It derives from a hydride of a 9H-purine.

Определение

A nitrogenous base found in DNA and RNA. Guanine has a purine ring structure.

Общее описание

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Guanine is one of the building blocks of both RNA and DNA that plays a significant role in protein biosynthesis as well as the storage of genetic information.