Clomazone

Описание

The molecular target site of clomazone has recently been determined. With clomazone, carotenoid synthesis is inhibited, but no intermediates in the carotenoidcommitted portion of the pathway accumulate (5,6). Synthesis of the derivatives of GGPP (gibberellic acid, phytol, carotenoids) is inhibited by clomazone (5–8). However, the synthesis of certain sesquiterpenoids and triterpenoids is not inhibited (9). Until recently, there was no credible report of the effect of clomazone on any enzyme of the terpenoid pathway (10–12). This was due to the fact that clomazone is a proherbicide and that the proper enzyme had not been tested.

Химические свойства

Depending purity, it may be clear and colorless to pale yellow or brownish liquid. Commercially available as emulsifiable concentrates that can be dissolved in water

Использование

Herbicide.

Определение

ChEBI: A oxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2-chlorobenzyl group at position 2 and two methyl groups at position 4.

Опасность

Moderately toxic by ingestion, inhalation, and skin contact. A reproductive hazard.

Сельскохозяйственное использование

Herbicide: Clomazone is a broad-spectrum herbicide used on rice, peas, pumpkins, soybeans, sweet potatoes, winter squash, cotton, tobacco and fallow wheat fields to control annual grasses and broadleaf weeds.

Торговое название

CERANO®; COLZOR TRIO®; COMMAND®; COMMENCE®, DIBEL®; FMC® 57020; GAMBIT®; MAGISTER®; MERIT®; STRATEGY®

Возможный контакт

Clomazone is a oxazolidione broadspectrum herbicide used on rice, peas, pumpkins, soybeans, sweet potatoes, winter squash, cotton, tobacco, and fallow wheat fields to control annual grasses and broadleaf weeds.

Метаболический путь

By the preparative incubation of clomazone with microorganisms that have the ability to metabolize clomazone, the metabolites are identified via major biotransformation reactions which involve hydroxylation at the 5-methylene carbon and one of the 3-methyl groups of the isoxazolidone ring and at the 3 0 -position of the phenyl ring. Minor metabolic routes include dihydroxylation on the phenyl ring, cleavage of the isoxazolinone ring, or complete removal of the isoxazolinone ring to form 2-chlorobenzyl alcohol. Under aerobic conditions of soils, degradation of clomazone proceeds primarily by CO2 evolution and the formation of bound soil residues. In flooded soils, clomazone is found rapidly to degrade via the formation of the reductive product N-[(2-chlorophenyl)methyl]-3-hydroxy-2,2- dimethylpropionamide. In tolerant soybean cell suspension cultures, the only metabolite identified is b-glycosyl-2-chlorobenzyl alcohol.

Перевозки

UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Несовместимости

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Утилизация отходов

Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.