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Diosgenin
- русский язык имя
- английское имяDiosgenin
- CAS №512-04-9
- CBNumberCB2685481
- ФормулаC27H42O3
- мольный вес414.63
- EINECS208-134-3
- номер MDLMFCD00016887
- файл Mol512-04-9.mol
химическое свойство
Температура плавления | 205-208°C |
альфа | D25 -129° (c = 1.4 in CHCl3) |
Температура кипения | 473.46°C (rough estimate) |
плотность | 1.0483 (rough estimate) |
показатель преломления | 1.4700 (estimate) |
температура хранения | 2-8°C |
растворимость | chloroform: 20 mg/mL, clear, slightly yellow |
форма | Solid |
пка | 15.02±0.70(Predicted) |
цвет | White to Pale Yellow |
оптическая активность | -12925 (c 1.4, CHCl3) |
Растворимость в воде | Soluble in chloroform (50 mg/ml), ethanol (83 mg/ml at 25°C), water (<1 mg/ml at 25°C), DMSO (<1 mg/ml at 25°C), and methanol. |
Мерк | 14,3295 |
БРН | 94582 |
LogP | 6.602 (est) |
Справочник по базе данных CAS | 512-04-9(CAS DataBase Reference) |
FDA UNII | K49P2K8WLX |
Справочник по химии NIST | Diosgenin(512-04-9) |
Коды опасности | Xi |
Заявления о рисках | 36/37/38 |
Заявления о безопасности | 26-36/37-24/25 |
WGK Германия | 2 |
RTECS | WH1450000 |
кода HS | 29329990 |
Diosgenin химические свойства, назначение, производство
Химические свойства
White to Off-White DolidВхождение
Primary sources of diosgenin (a steroidal sapogenin) include Smilax China, Rhizoma polygonati, Solanum incanum, Solanum xanthocarpum, Dioscorea villosa, Trigonella foenum graecum (fenugreek), and Dioscorea Linn (wild yams). It is commercially obtained from wild yam tubers and rootstock[1-2].![Diosgenin Diosgenin](/NewsImg/2024-03-22/6384670370199180831508675.png)
Использование
Aglicone of saponin dioscin. Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. e and Progesterone.Общее описание
Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source.разработк И противоопухолевых препаратов
It is a steroidal saponin and legumes and yams are the rich sources of it. It is a notoriousprecursor of several synthetic steroidal drugs. It suppresses growth of cells andinduces apoptosis in human osteosarcoma, colon cancer, and leukemia. Its anticancermechanism is by arresting the cell cycle, disrupting the calcium homeostasis,activating p53, releasing apoptosis inducing factors, and modulating caspase-3activity. It suppresses NF-κB activation induced by TNF as a result of DNA binding,IκBα kinase activation, degradation, phosphorylation, p65 nuclear translocation,and phosphorylation. It suppresses proliferation and invasion and induces apoptosisby downregulation of cFLIP, cyclin-D1, TRAF1, COX-2, c-myc, Bfl-1/A1, BclxL,IAP1, Bcl-2, and MMP-9 (Aggarwal et al. 2008; Raju and Mehta 2008).Методы очистки
Crystallise diosgenin from acetone, and chromatograph it on Al2O3 and elute with *C6H6/Et2O (9:1), then recrystallise it from MeOH. Its solubility is ~4% in H2O and 5% in CHCl3. The acetate crystallises from AcOH with m 198o; and has [] D 20 -119o (pyridine). [Marker et al. J Am Chem Soc 65 1199 1943. Mazur et al. J Am Chem Soc 82 5889 1960, Beilstein 19 IV 862.]Diosgenin запасные части и сырье
сырьё
запасной предмет
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Diosgenin поставщик
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