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Хинидин дигидрат сульфата
- английское имяQuinidine sulfate dihydrate
- CAS №6591-63-5
- CBNumberCB2471189
- ФормулаC20H26N2O6S
- мольный вес422.5
- EINECS678-472-8
- номер MDLMFCD00149346
- файл Mol6591-63-5.mol
химическое свойство
Температура плавления | 212-214 °C (dec.)(lit.) |
альфа | [α]D20 +260~+270° (c=5, dil. HCl.10min) |
показатель преломления | 275 ° (C=2, 0.1mol/L HCl) |
температура хранения | under inert gas (nitrogen or Argon) at 2-8°C |
растворимость | Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone. |
цвет | White to Off-White |
Растворимость в воде | Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml). |
Чувствительный | Light Sensitive |
Мерк | 14,8060 |
ИнЧИКей | AKYHKWQPZHDOBW-ZAXYGKDDNA-N |
SMILES | [C@@H]([C@@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r| |
Справочник по базе данных CAS | 6591-63-5(CAS DataBase Reference) |
FDA UNII | J13S2394HE |
Коды опасности | Xn |
Заявления о рисках | 22-20/21/22 |
Заявления о безопасности | 13-36 |
РИДАДР | UN 2811 6.1/PG III |
WGK Германия | 3 |
RTECS | VA5605000 |
TSCA | Yes |
Класс опасности | 6.1 |
Группа упаковки | III |
кода HS | 2939200050 |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Хинидин дигидрат сульфата химические свойства, назначение, производство
Описание
Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug. Quinidine sulfate dihydrate is a white, odorless crystalline substance that has a bitter flavor. It has limited solubility in water and alcohol but dissolves easily in chloroform and ether. This compound is effective against bacteria resistant to erythromycin, including staphylococci and streptococci, and works by inhibiting cellular ATPases.Химические свойства
Quinidine sulfate dihydrate is white to light yellow crystal powdeИспользование
Quinidine sulfate dihydrate (cas# 6591-63-5) is the hydrated, sulfate salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.прикладной
Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.Общее описание
Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.Клиническое использование
Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na+ current bybinding the open ion channels (i.e., state A). The decreasedNa+entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na+, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.Хинидин дигидрат сульфата поставщик
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