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2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- русский язык имя
- английское имя2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
- CAS №1609394-10-6
- CBNumberCB23122644
- ФормулаC10H12N4O
- мольный вес204.23
- номер MDLMFCD30489435
- файл Mol1609394-10-6.mol
химическое свойство
Температура кипения | 437.6±55.0 °C(Predicted) |
плотность | 1.29±0.1 g/cm3(Predicted) |
растворимость | DMSO (Slightly) |
пка | 3.45±0.10(Predicted) |
форма | Solid |
цвет | Pale Orange to Brown |
InChI | InChI=1S/C10H12N4O/c1-14-6-12-10(13-14)7-4-3-5-8(11)9(7)15-2/h3-6H,11H2,1-2H3 |
ИнЧИКей | FIAZRZSVFOMYSD-UHFFFAOYSA-N |
SMILES | C1(N)=CC=CC(C2N=CN(C)N=2)=C1OC |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H301+H311+H331:Токсично при проглатывании, при контакте с кожей или при вдыхании.
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оператор предупредительных мер
P261:Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P301+P310:ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P311:Обратиться за медицинской помощью.
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline химические свойства, назначение, производство
Химические свойства
white solidИспользование
2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline is used in the preparation of pyridazines which is a heterodimeric cytokines modulators for treatment of diseases.Синтез
To a high pressure reactor flushed with nitrogen were charged methanol (8.0 kg/kg) and Compound 6 (1.0 kg). With careful exclusion of oxygen, sodium bicarbonate (0.6 kg/kg, 2.0 equiv.) and Pd/C (10% loading, 50 % wet, 0.02 kg/kg) were added. The reactor was pressurized with hydrogen (41-46 psi), and the reaction mixture was aged at 20 °C for 6 h then heated to 45 °C and aged till reaction reached completion. The reactor was flushed with nitrogen, and the reaction crude was filtered to remove Pd/C. Methanol (5 kg/kg) was used to aid the transfer. The combined filtrates were distilled under vacuum until total volume became approximately 2.5 L/kg. Water (10 kg/kg) was added, and the crude was distilled under vacuum until total volume became approximately 2.5 L/kg. The crude was heated to 70 °C. Brine (25 wt%, 9.0 kg/kg) was added, and the resulting crude was agitated for 6 h at 70 °C. After cooling down to 0 °C, the crude was further aged for 6 h. Product was isolated by filtration. The cake was washed with brine (pre-cooled to 0 °C, 25 wt%, 2.0 kg/kg), and dried under vacuum at 45 °C. 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline was isolated in 99 AP and 88% yield.![synthesis of 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline synthesis of 2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline](/NewsImg/2023-02-07/6381136549501210496936276.jpg)
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline запасные части и сырье
запасной предмет
2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline поставщик
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