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WZ8040
- русский язык имя
- английское имяWZ8040
- CAS №1214265-57-2
- CBNumberCB22501011
- ФормулаC24H25ClN6OS
- мольный вес481.01
- EINECS-0
- номер MDLMFCD18074511
- файл Mol1214265-57-2.mol
химическое свойство
плотность | 1.37 |
температура хранения | Store at -20°C |
растворимость | ≥24.05 mg/mL in DMSO; insoluble in H2O; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic |
форма | solid |
пка | 12.94±0.70(Predicted) |
цвет | Light yellow to green yellow |
WZ8040 химические свойства, назначение, производство
Описание
WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC50 values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFRDel E746_A750 and EGFRL858R mutations conferring gefitinib sensitivity and the EGFRDel E746_A750/T790M mutation conferring gefitinib resistance (IC50s = 2, 6, and 6 nM in Ba/F3 cells), over wild-type EGFR (IC50 = 1,820 nM in HN11 cells) but also inhibits ERBB2Ins G776V,C and wild-type ERBB2 (IC50s = 20 and 32 nM, respectively, in Ba/F3 cells). WZ8040 inhibits proliferation of PC-9 cells harboring the EGFRDel E746_A750 mutation and gefitinib-resistant PC-9 GR cells harboring the EGFRT790M resistant allele (EC50s = 6 and 8 nM, respectively).Использование
WZ8040 is an irreversiblely EGFR T790M inhibitor (IC50<10nM).WZ8040 поставщик
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