N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
- русский язык имя
- английское имяN-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
- CAS №925434-55-5
- CBNumberCB22489951
- ФормулаC25H23N7OS
- мольный вес469.56
- номер MDLMFCD14584468
- файл Mol925434-55-5.mol
химическое свойство
| Температура плавления | 221℃ |
| плотность | 1.46 |
| температура хранения | -20C |
| растворимость | DMSO:5.0(Max Conc. mg/mL);10.65(Max Conc. mM) |
| форма | Yellow solid |
| пка | 11.19±0.70(Predicted) |
| цвет | Light yellow to yellow |
| FDA UNII | DX3FHY76FZ |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide химические свойства, назначение, производство
Общее описание
A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9 μM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide запасные части и сырье
сырьё
- tert-butyl 4-((6-(2-aMinophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl)piperazine-1-carboxylate
- 6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID
- (6-(2-nitrophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl Methanesulfonate
- ЭТИЛОВЫЙ ЭФИР 6-(2-НИТРО-ФЕНИЛ)-ИМИДАЗО[2,1-B]ТИАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ
- 3-ГИДРОКСИМЕТИЛ-6- (2-НИТРОФЕНИЛ) ИМИДАЗО [2,1-B] ТИАЗОЛ
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N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide поставщик
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