1,4-дигидроникотинаМид рибозид

Использование

Reduced Nicotinamide Riboside is a precursor which is an essential cofactor and substrate for many cells.

Биологическая активность

1,4-dihydronicotinamide riboside (NRH) is a potent NAD+ concentration enhancer both in vitro and in vivo. Researchers found that, after administration of NRH to mammalian cells, the NAD+ concentration increased by 2.5–10fold over control values in just one hour. Their findings demonstrate that the use of NRH is more effective than either NR or NMN. Moreover, NRH considerably enhances the NAD+/NADH ratio in the cultured cells without induction of apoptotic markers or a substantial increase in cell lactate levels. More recently, Canto et al. have found that contrary to the NR pathway, NRH uses different steps and enzymes to synthesize NAD+. That explains why NRH is a more effective and faster NAD+ precursor than NR in mammalian cells. In experiments with mice, the same researchers have also demonstrated that NRH is orally bioavailable as an NAD+ precursor and prevents cisplatin-induced acute kidney injury. In addition to increasing NAD+ levels, NRH can also deplete some genotoxins, such as hydrogen peroxide and methylmethane sulfonate. As a result, the mouse cells treated with NRH are resistant to cell death[1].