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U-69593
- русский язык имя
- английское имяU-69593
- CAS №96744-75-1
- CBNumberCB0432261
- ФормулаC22H32N2O2
- мольный вес356.5
- номер MDLMFCD05664586
- файл Mol96744-75-1.mol
химическое свойство
Температура плавления | 120-123℃ |
Температура кипения | 518.7±50.0 °C(Predicted) |
плотность | 1.13 |
RTECS | CY1490060 |
температура хранения | 2-8°C |
растворимость | H2O: 14 mg/mL |
форма | solid |
пка | 9.15±0.20(Predicted) |
цвет | white |
оптическая активность | [α]/D +7.8°, c = 0.825 in methanol(lit.) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | J5S4K6TKTG |
U-69593 химические свойства, назначение, производство
Использование
U-69593 is a selective κ-opioid receptor agonist. A safe opioid analgesic.Определение
ChEBI: U69593 is a monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine. It has a role as a kappa-opioid receptor agonist, an anti-inflammatory agent and a diuretic. It is an oxaspiro compound, a N-alkylpyrrolidine, an organic heterobicyclic compound and a monocarboxylic acid amide.Биологические функции
U-69593 is a single enantiomer with very high selectivity for the kappa receptor in vitro (mu/kappa ratio = 484). It was radiolabelled by a catalytic exchange of tritium for the two aromatic chlorine substituents of the precursor. This ligand is commercially available and has been widely used as a radiolabel for the kappa receptor.in spinal cordslice preparations from the 9-16-day-old rat,U-69593 produced a na-loxone-reversible depression of spontaneous and electrically evoked activityin dorsal horn neurones.
Биохимия/физиол Действия
U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.U-69593 поставщик
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