МРК 560
- английское имяMRK 560
- CAS №677772-84-8
- CBNumberCB02538282
- ФормулаC19H17ClF5NO4S2
- мольный вес517.92
- номер MDLMFCD09970622
- файл Mol677772-84-8.mol
химическое свойство
| Температура кипения | 580.1±60.0 °C(Predicted) |
| плотность | 1.57±0.1 g/cm3(Predicted) |
| температура хранения | Store at 4°C |
| растворимость | <51.79mg/ml in DMSO; <25.9mg/ml in ethanol |
| форма | solid |
| пка | 5.97±0.40(Predicted) |
| цвет | White |
МРК 560 химические свойства, назначение, производство
Описание
MRK-560 is a potent inhibitor of γ-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-β (1-40) (Aβ40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer''s disease.Использование
MRK 560 acts as a y-secretase inhibitor that is orally bioavailable and potent and may be used in a therapeutic strategy to counter low amyloid (β) production in Alheimer’s disease.МРК 560 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +1-781-999-5354 +1-00000000000 |
United States | 19892 | 58 | |
| +8618327326525 | China | 8474 | 58 | |
| +1-+1(833)-552-7181 | United States | 57511 | 58 | |
| 18149758185 | China | 3460 | 58 | |
| 021-13816613772 13816613772 |
China | 377 | 55 | |
| 888-539-0666 | United States | 8449 | 60 | |
| 17754423994 17754423994 |
China | 8014 | 62 | |
| 21-31433387 15618786686 |
China | 2981 | 58 | |
| China | 19785 | 58 | ||
| 18818260767 | China | 11289 | 58 |