4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
- русский язык имя
- английское имя4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-
- CAS №663619-89-4
- CBNumberCB02456412
- ФормулаC21H24N4O2
- мольный вес364.44
- номер MDLMFCD11113209
- файл Mol663619-89-4.mol
химическое свойство
| Температура плавления | 198-201oC |
| Температура кипения | 557.3±60.0 °C(Predicted) |
| плотность | 1.25±0.1 g/cm3(Predicted) |
| температура хранения | Hygroscopic, Refrigerator, under inert atmosphere |
| растворимость | DMSO (Slightly), Methanol (Very Slightly) |
| пка | 3.90±0.50(Predicted) |
| форма | Pale yellow solid. |
| цвет | Off-White to Pale Yellow |
| FDA UNII | 6L28AW98TH |
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- химические свойства, назначение, производство
Использование
TGX-221 is a potent, selective, and cell permeable inhibitor of Phosphatidylinositol 3-kinase (PI3K) p110β.Общее описание
A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC50 = 0.005, 0.1, 5, and ≥3.5 μM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 μM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.Биохимия/физиол Действия
Cell permeable: yes4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- поставщик
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