2'-Deoxyguanosine monohydrate
- русский язык имя
- английское имя2'-Deoxyguanosine monohydrate
- CAS №312693-72-4
- CBNumberCB0209021
- ФормулаC10H15N5O5
- мольный вес285.26
- EINECS628-392-4
- номер MDLMFCD00150760
- файл Mol312693-72-4.mol
химическое свойство
Температура плавления | >300 °C (dec.)(lit.) |
температура хранения | Keep in dark place,Sealed in dry,Room Temperature |
растворимость | NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown |
форма | powder |
пка | pK1:2.5(+1) (25°C,μ=0.1) |
цвет | White to Off-White |
БРН | 39814 |
InChI | InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/s3 |
ИнЧИКей | LZSCQUCOIRGCEJ-FPKZOZHISA-N |
SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)C[C@@H]1O |&1:2,4,17,r| |
FDA UNII | G9481N71RO |
Коды опасности | Xn,T | |||||||||
Заявления о рисках | 22-25 | |||||||||
Заявления о безопасности | 45 | |||||||||
WGK Германия | 3 | |||||||||
F | 10-23 | |||||||||
TSCA | Yes | |||||||||
кода HS | 2934999090 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
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оператор предупредительных мер
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P403:Хранить в хорошо вентилируемом месте.
2'-Deoxyguanosine monohydrate химические свойства, назначение, производство
Описание
2''-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 μM, respectively). 2''-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 μM. It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems. 2''-Deoxyguanosine (>1 μM) also induces relaxation of precontracted isolated bovine lingual artery.Химические свойства
White to Off-White Solid. Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.Определение
ChEBI: 2'-Deoxyguanosine monohydrate is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.прикладной
2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes.
Биологические функции
lu et al. found that 2'-Deoxyguanosine (2-dG) is a key immune signaling molecule in plant–microbe interactions and that Arabidopsis VENOSA4 (VEN4) is essential for plant immunity. 2-dG is the immunoreactive component in ZhiNengCong (ZNC). This compound induced classical immune responses, including ROS production, allose accumulation and MPKs phosphorylation, and upregulated the expression of plant immunity-associated genes. In addition, 2-dG-induced plant immunity requires salicylic acid (SA) receptor NPR1 (but not SA), ethylene (ET) signaling, pattern-recognition receptors/coreceptors (PRRs/coreceptors) and the ATP receptor P2K1[1]. VEN4 was involved in 2-dG biosynthesis and could convert dGTP to 2-dG.2'-Deoxyguanosine monohydrate поставщик
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