| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
|
mouse
|
LD50
|
intraperitoneal
|
2500ug/kg (2.5mg/kg)
|
|
Biochemical Pharmacology. Vol. 30, Pg. 771, 1981.
|
|
mouse
|
LD50
|
intravenous
|
20mg/kg (20mg/kg)
|
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
|
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
|
|
mouse
|
LD50
|
oral
|
196mg/kg (196mg/kg)
|
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
|
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
|
|
rabbit
|
LDLo
|
oral
|
250mg/kg (250mg/kg)
|
|
Journal of Medical Research. Vol. 42, Pg. 461, 1919.
|
|
rat
|
LD50
|
intraperitoneal
|
14700ug/kg (14.7mg/kg)
|
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
|
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
|
|
rat
|
LD50
|
intravenous
|
17100ug/kg (17.1mg/kg)
|
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
|
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
|
|
rat
|
LD50
|
oral
|
501mg/kg (501mg/kg)
|
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
|
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.
|
|
rat
|
LD50
|
subcutaneous
|
350mg/kg (350mg/kg)
|
|
Progress in Medical Chemistry. Vol. 15, Pg. 211, 1977.
|
|
rat
|
LD50
|
subcutaneous
|
350mg/kg (350mg/kg)
|
MUSCULOSKELETAL: JOINTS
|
Progress in Medical Chemistry. Vol. 15, Pg. 211, 1977.
|
