SGC0946

Product Description

SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM; selectively kill mixed lineage leukaemia cells.

Target

DOT1L

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IC50 Value

0.3nM

Diseases and Conditions

Cancer

体外

体内

分子量

618.57

储存条件

分子式

C₂₈H₄₀BrN₇O₄

CAS:

1561178-17-3

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

溶解度

体外

Ethanol

100mg/mL(161.66mM)

DMSO

100mg/ml(161.66 mM)

Water

<1mg/ml

体内

* <1 mg/ml refers to the product slightly soluble or insoluble

浓度溶解体积质量

1mg

5mg

10mg

1mM

1.6166mL

8.0832mL

16.1663mL

5mM

0.3233mL

1.6166mL

3.2333mL

10mM

0.1617mL

0.8083mL

1.6166mL

50mM

0.0323mL