PLX-3397

Product Description

Pexidartinib (PLX3397) is an oral, potent mutil-targeted receptor tyrosine kinase inhibitor of CSF-1R, Kit, and Flt3 with IC50 of 20 nM, 10 nM and 160 nM, respectively. Phase 3.

Target

Kit

Flt3

CSF-1R

View more

IC50 Value

10nM

160nM

20nM

Diseases and Conditions

Cancer

体外

体内

分子量

417.81

储存条件

分子式

C₂₀H₁₅ClF₃N₅

CAS:

1029044-16-3

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

溶解度

体外

Ethanol

DMSO

83mg/ml(198.65 mM)

Water

<1mg/ml

体内

* <1 mg/ml refers to the product slightly soluble or insoluble

浓度溶解体积质量

1mg

5mg

10mg

1mM

2.3934mL

11.9672mL

23.9343mL

5mM

0.4787mL

2.3934mL

4.7869mL

10mM

0.2393mL

1.1967mL

2.3934mL

50mM