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  • DDX39A抗体—艾普蒂
  • DDX39A抗体—艾普蒂
  • DDX39A抗体—艾普蒂

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DDX39A抗体—艾普蒂

Rabbit Polyclonal DDX39A Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-20

上海切尔齐生物科技有限公司

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电话：027-19371278702拨打
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邮箱：ruihening88@163.com

产品详情:

中文名称：
DDX39A抗体
英文名称：
Rabbit Polyclonal DDX39A Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 4948 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
DDX39A

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesBAT1; DDXL; BAT1L; DDX39; URH49
WB Predicted band size49 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human DDX39A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 and Jurkat cell lysates, Primary antibody: P09605(DDX39A Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09605(DDX39A Antibody) at dilution 1/65. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09605(DDX39A Antibody) at dilution 1/65. (Original magnification: ×200)    


           

参考文献

以下是3-4条关于 **DDX39A抗体** 的参考文献示例(注：以下为模拟虚构内容，实际文献请通过学术数据库查询)：

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1. **文献名称**: *DDX39A interacts with the splicing machinery and promotes RNA splicing in human cells*

**作者**: Smith A, et al.

**摘要**: 本研究利用DDX39A特异性抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，发现DDX39A与剪接体复合物相互作用，并通过调控前体mRNA剪接影响基因表达。

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2. **文献名称**: *DDX39A expression correlates with cancer progression and immune infiltration*

**作者**: Zhang Y, et al.

**摘要**: 通过免疫组化(IHC)结合DDX39A抗体分析肿瘤组织样本，发现DDX39A在多种癌症中高表达，其水平与患者预后不良及肿瘤微环境中的免疫细胞浸润相关。

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3. **文献名称**: *DDX39A is essential for viral RNA unwinding and innate immune signaling*

**作者**: Lee H, et al.

**摘要**: 使用DDX39A敲除细胞系及特异性抗体验证，发现DDX39A通过解旋病毒RNA促进RIG-I信号通路激活，在抗病毒天然免疫应答中发挥关键作用。

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4. **文献名称**: *Structural insights into the ATP-dependent RNA helicase activity of DDX39A*

**作者**: Tanaka K, et al.

**摘要**: 通过抗体制备和冷冻电镜技术解析DDX39A蛋白结构，揭示了其依赖ATP的RNA解旋酶活性机制，为靶向DDX39A的药物设计提供依据。

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如需真实文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词 "DDX39A antibody" 或结合具体研究场景筛选。

       

背景信息

DDX39A (also known as UAP56 or BAT1) is a member of the DEAD-box RNA helicase family, which plays critical roles in RNA metabolism, including pre-mRNA splicing, nuclear export, and translation. This ATP-dependent enzyme facilitates the unwinding of RNA secondary structures and participates in spliceosome assembly by recruiting key components to nascent transcripts. Dysregulation of DDX39A has been implicated in cancer, neurodegenerative diseases, and viral infections, highlighting its importance in cellular homeostasis.

Antibodies targeting DDX39A are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate DDX39A's role in RNA processing and disease mechanisms. For instance, researchers employ these antibodies to analyze DDX39A overexpression in malignancies or its reduced activity in aging-related neurological disorders. Validated antibodies often undergo specificity checks using knockout cell lines or siRNA knockdown to ensure minimal cross-reactivity with homologous proteins like DDX39B. Commercial antibodies typically cite applications in detecting the ~50 kDa protein across human, mouse, and rat samples. Ongoing research also explores DDX39A's potential as a therapeutic target or biomarker, driving demand for reliable antibody reagents. Suppliers such as Abcam, Cell Signaling Technology, and Santa Cruz Biotechnology provide DDX39A antibodies, though performance may vary depending on epitope regions and experimental conditions.

       
DDX39A抗体;DDX39A;DDX39A Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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