文章标题：Cu2+-loaded hydrogel coating mimicking the cell membrane to enhance anticorrosion, hemocompatibility, endothelialization, and antibacterial activities of magnesium alloys
作者列表：Pan Changjiang, Yang Naiquan, Chen Jie, Zhang Qiuyang, Wang Yunbing
影响因子：4.9
期刊：Science China-Technological Sciences
发表时间：2026-4-7
DOI:10.1007/s11431-025-3208-4
文献主题：Abstract
For magnesium alloys (MAs) in biodegradable vascular stents, key issues, such as over-fast degradation in vivo, inferior hemocompatibility and reendothelialization, and limited antibacterial properties, have not yet been effectively addressed. In this study, following alkali heat treatment and self-assembly of allyltrimethoxysilane (ATMS) on the MA surface, a 2-methacryloyloxyethyl phosphorylcholine (MPC) and glycidyl methacrylate (GMA) di-block hydrogel coating mimicking the cell membrane was covalently bonded to the substrate using ultraviolet (UV) polymerization. Subsequently, carboxymethyl chitosan/Cu2+ complex was anchored onto the hydrogel surface to obtain a cell membrane-mimicking coating with the ability to catalytically generate nitric oxide (NO) (CMC/Cu). The as-prepared coating could markedly improve the surface wettability and anticorrosion of MAs, and the corrosion current density was reduced from 1.21 × 10−5 A cm−2 of the pristine MA to 3.01 × 10−7 A cm−2 of CMC/Cu. Moreover, it could significantly enhance the hemocompatibility of MA; the surface fibrinogen adsorption and hemolysis rate were lowered from 1727 ng mL−1 and 31% (the pristine MA) to 83 ng mL−1 and 0.4% (CMC/Cu), respectively, and the platelet adhesion and activation were inhibited remarkably. Meanwhile, the coating could significantly facilitate the growth of endothelial cells (ECs) while inhibiting the adhesion and proliferation of smooth muscle cells (SMCs), and upregulate the expression of VEGF (vascular endothelial growth factor) and CD31 (platelet EC adhesion molecule) in ECs, thereby significantly improving the reendothelialization of MA. Further results indicated that Cu2+ in the coating could continuously catalyze NO donors to liberate NO, further enhancing the hemocompatibility and endothelialization of MAs. In addition, the excellent anti-biofouling of MPC, along with the antibacterial effects of CMC/Cu2+, endowed MAs with excellent bacteriostatic and antibacterial properties. Therefore, the biomimetic coating of this study can simultaneously ameliorate the corrosion resistance, hemocompatibility, endothelialization ability, and antibacterial performance of MAs, providing a novel strategy for the multifunctional surface modification of MAs.
