| Name | Dimethyl fumarate |
| Description | Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis. |
| In vitro | METHODS: Primary cortical cultures or hippocampal HT22 cells were treated with Dimethyl fumarate (10 µM) and glutamate for 24 h. Cell viability was measured by Cell Titer Blue (CTB) assay.
RESULTS: Pre-incubation with 10 µM MMF Dimethyl fumarate for 24 h protected primary cortex cultures and hippocampal HT22 cells from oxidized glutamate toxicity. [1]
METHODS: Tumor cells CT26 were treated with Dimethyl fumarate (100 µM) for 3-24 h. LDH release was detected by LDH cytotoxicity assay kit.
RESULTS: Dimethyl fumarate time-dependently increased LDH release, which reflected necrotic cell death. [2] |
| In vivo | METHODS: To study the effects on Friedreich's ataxia (FA), Dimethyl fumarate (110 mg/kg) was administered orally to a FXNKD mouse model of FA once daily for 18 weeks.
RESULTS: Dimethyl fumarate rescued these enzyme activities in the brain of the FXNKD mouse model and rescued frataxin and cytochrome oxidase expression in the brain, cerebellum, and quadriceps muscle. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 15 mg/mL (104.07 mM), Sonication is recommended.
10% DMSO+90% Saline : 1.5 mg/mL (10.41 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
Ethanol : 7.2 mg/mL (49.95 mM), Sonication is recommended.
5% DMSO+95% Saline : 0.29 mg/mL (2.01 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
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| Keywords | sclerosis | ROS | ReactiveOxygenSpecies | Reactive Oxygen Species | neuroprotective | KEAP1-Nrf2 | Keap1-Nrf2 | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | EndogenousMetabolite | Endogenous Metabolite | Dimethyl Fumarate | Dimethyl fumarate | Dimethyl | brain-penetrant | Autophagy | Antioxidant | anti-inflammatory |
| Inhibitors Related | Sucrose | Emtricitabine | Hydroxychloroquine | Daidzein | Lamivudine | Guanidine hydrochloride | Ferulic Acid | Formamide | Paeonol | Glycerol | Thymidine | 3-Indoleacetic acid |
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