氰美马嗪
氰美马嗪 性质
| 熔点 | 90-95°C |
|---|---|
| 沸点 | bp0.2-0.5 205-220° |
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 酸度系数(pKa) | 9.31±0.28(Predicted) |
| 形态 | 粉末 |
| 颜色 | 淡黄色至黄绿色 |
| InChI | 1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3 |
| InChIKey | SLFGIOIONGJGRT-UHFFFAOYSA-N |
| SMILES | CC(CN(C)C)CN1c2ccccc2Sc3ccc(cc13)C#N |
氰美马嗪 用途与合成方法
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5-HT 2A Receptor 1.5 nM (Ki) |
5-HT 2C Receptor 12 nM (Ki) |
5-HT 3 Receptor 75 nM (Ki) |
Cyamemazine exhibits a high affinity for dopamine receptors, which is consistent with its antipsychotic activity. The antagonist activity of Cyamemazine at muscarinic receptors is consistent with its affinity for M 1 ( K i = 13 nM), M 2 ( K i = 42 nM), M 3 ( K i = 321 nM), M 4 ( K i = 12 nM), and M 5 ( K i = 35 nM) receptors.
Cyamemazine behaves as an antagonist at the 5-HT 3 , 5-HT 2C , and 5-HT 2A receptors in 5-HT 3 -dependent contraction of isolated guinea pig ileum and bradycardic responses in rats, in 5-HT 2C -dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT 2A -dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Cyamemazine antagonizes 5-HT 3 and 5-HT 2C receptors and that this effect is partially involved in its therapeutic activity in anxiety disorders. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum.
安全信息
| 危险品标志 | Xi,N |
|---|---|
| 危险类别码 | 50 |
| 安全说明 | 61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 危害水生环境-急性危害 类别1 危害水生环境-长期危害 类别1 |
| 毒性 | LDLo oral in man: 107mg/kg |
氰美马嗪 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-14264 | 氰美马嗪 | 3546-03-0 | 5mg | 800 |
| 2025-12-22 | HY-14264 | 氰美马嗪 | 3546-03-0 | 10 mM * 1 mLin DMSO | 880 |
