Hydrion,Robert and
Carriere,France,1970
Ambuside is used in biological studies in the discovery of novel trypanosomicidal drug like chemicals.
ChEBI: Ambuside is a sulfonamide.
Preparation of 2-Allylsulfamyl-4-Sulfamyl-5-Chloro-N-(3-Hydroxy-2-
Butenylidene)Aniline or Ambuside: 2-allylsulfamyl-5-chloro-4-
sulfamylanilinemonohydrate (6.9 grams, 0.020 mol) was dissolved in 14 ml
acetylacetaldehyde dimethylacetal at room temperature and the viscous
solution was filtered. Addition of 6 drops of 10:1 H2O/concentrated HCl, and
stirring for 20 hours gave a heavy suspension. Dilution with 150 ml of
ethanol, collection of the solid, washing twice with 40 ml portions of ethanol,
and drying gave 6.2 grams (78%) of product, MP 204-206°C.
Diuretic, Antihypertensive
