Metaldehyde (CAS: 108-62-3) is a polymer of acetaldehyde
that is used as a pesticide against snails and slugs, and also as
a fuel. It was discovered by von Liebig in 1835, and a century
later its use as a molluscicide was proposed by Gimingham and
Newton in 1937. It is manufactured by reacting acetaldehyde
with various acids at a low temperature. As a molluscicide,
metaldehyde is used for controlling slugs and snails in gardens
of a variety of vegetable and ornamental crops. For this purpose
it is available in both solid and liquid formulations with
metaldehyde concentrations ranging from 1.8 to 8% in pellet
form, or in concentrations of up to 20% in liquid formulations.
Some metaldehyde formulations may consist of other pesticides,
such as arsenic; while others may contain toxic solvents
like ethylene glycol. Therefore, a thorough forensic analysis of
the product is recommended to assess complete risk associated
with ingestion of these products.
Children under the age of 3 years and pets are most
commonly poisoned by ingestion of pellets or cakes containing
metaldehyde. Intoxication by metaldehyde is typically acute,
characterized initially by gastrointestinal and subsequently
followed predominantly by neurologic signs. Vomiting, diarrhea,
ataxia, tremors, convulsions, and hyperthermia are
among the most common toxic signs in children and animals.
Other clinical signs in children include mental confusion,
muscle cramps and tremors, loss of consciousness, and coma.
The proximate neurotoxic mechanisms are not known but
reduced levels of neurotransmitters such as serotonin and
g-aminobutryric acid (GABA) are implicated. Delayed effects of
acute exposure include hepatotoxicity characterized by hepatic
necrosis and increased serum liver enzymes. In general, males
metabolize metaldehyde twice as fast as females. Therefore,
female animals are more sensitive to metaldehyde poisoning
compared to males. Most of the neurotoxic signs are seen at
dose levels greater than 100 mg of metaldehyde per kilogram.
Developmental studies have shown that metaldehyde exposure
during pregnancy does not adversely affect fetuses.
Chronic metaldehyde exposure is unlikely. However,
experimental research has shown that metaldehyde is toxic
under chronic exposure conditions. In males, chronic metaldehyde
exposure causes testicular atrophy and is also toxic to
the prostate gland. It causes atrophy of the prostate gland. It is
not clear whether the effects on male gonads are due to
endocrine disruption or through a different mechanism. There
is also suggestive evidence of carcinogenic potential based on
the presence of benign tumors in female rats and mice of both
sexes.
Provided treatment is initiated early in cases of acute
exposure, prognosis is good. In dogs, the mortality rate in
a recently completed study was 16%. Because there is no
specific antidote, treatment consists of decontamination
measures and symptomatic therapy. Recent formulations of
metaldehyde pesticides contain denatonium benzoate,
a bittering agent. The purpose of adding the bittering agent
is to deter excessive ingestion of the products. This, along
with new labeling guidelines highlighting the risk to children
and pets has caused annual cases to drop significantly
since 2006.
white fine crystalline powder
Metaldehyde is a white crystalline powder
with a mild menthol odor.
There are over 50 pesticides containing metaldehyde registered
for use in the United States.
It is commonly used as a pesticide against slugs and snails. It
is formulated in ready to use liquid, paste, granules, pellets,
minipellets, or meal baits. It is also used as a camping fuel. It
may be purchased in a tablet form for the latter use.
ChEBI: Metaldehyde is a member of the class of tetroxocanes that is 1,3,5,7-tetroxocane which carries four methyl groups at positions 2,4,6 and 8. It is a potent molluscicide and the active ingredient in most slug pellets used for crop protection. It has a role as a molluscicide and a fuel.
Flammability and Explosibility
Flammable
Molluscicide: A tetramer of acetaldehyde, metaldehyde is a molluscicide used in a variety of vegetable and ornamental
crops in the field or greenhouse. It may be formulated
with or without calcium arsenate and is also available in a
mixed formulation with thiram. A U.S. EPA restricted Use
Pesticide (RUP).
ANTIMILACE®; ARIOTOX®;
CEKUMETA®; DEADLINE®; DURHAM®;
HALIZAN®; LIMATOR®; META®; METASON®;
NAMEKIL®; SLUG-TOX®; TRAILS END®
Contact and stomach action. Decreases the concentration of gamma-aminobutyric acid, an inhibitory neurotransmitter that causes CNS excitation.
Human poison by ingestion. Human systemic effects by ingestion: convulsions or effect on seizure threshold. Moderately toxic by inhalation and skin contact. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALDEHYDES.
In a 1000-liter reactor, 560 kg of acetaldehyde at 0C is put in, and about 40 kg of ether is added and cooled to .
-15C. The prepared acid catalyst, i.e., about 4 kg of hydrochloric acid, about 1 kg of ether, about 1 kg of pyridine, about of brominal.
0.5kg, pyridine about 1kg, bromoxynil about , and hydroxylamine hydrochloride about 0.3kg, were added to the polymerization kettle under constant stirring and cooling, and the temperature of the polymerization kettle was observed to control .
Observe the polymerization kettle temperature control to control the rate of acid catalyst addition, so that the polymerization reaction temperature in the polymerization kettle does not exceed 0 , the acid catalyst is added to the polymerization kettle.
After the acid catalyst is added, the temperature in the polymerization kettle is maintained at -10~-5 for about 3 hours with constant stirring and cooling, and then it can be released from the polymerization kettle and filtered, and the solid is removed from the polymerization kettle.
Can be released from the polymerization kettle for filtration, the solids can be obtained after washing and drying white crystalline tetrameric acetaldehyde. The filtrate is sent to distillation .
Kettle heating, add sulfuric acid as a catalyst, filtrate in the trimerization of acetaldehyde depolymerization, control depolymerization of the top temperature of the tower at 20 21 , acetaldehyde and ethyl ether distillation separated out, ready for the next feeding use.
It is used as a poison for slugs and
snails, and as a fuel in small heaters.
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. 1716 Metaldehyde If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Metaldehyde is of low persistence in the soil. It is degraded
aerobically with a half-life of approximately 67 days to inactive
residues. Metaldehyde is soluble in water. Metaldehyde
undergoes rapid hydrolysis to acetaldehyde in an aquatic
environment.
Color Code—Red: Flammability Hazard: Store in a flammable storage area. Prior to working with metaldehyde you should be trained on its proper handling and storage. Store in tightly closed containers in a cool, wellventilated area away from strong oxidizers. Where possible, automatically transfer material from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.
UN1332 Metaldehyde, Hazard Class: 4.1;
Labels: 4.1-Flammable solid
The toxic mechanism in snails and slugs is different from that
in mammals and birds. Metaldehyde irreversibly damages
mucous secreting cells of snails and slugs on which these
organisms depend. In animals and birds, the proximate toxic
mechanism of metaldehyde is not known, but is either due
to toxicity of metaldehyde itself or of its metabolite acetaldehyde
on the brain and other tissues. The fundamental
neurotoxic molecular mechanisms are not known, but
a depression of serotonin and GABA is suspected to play
a role.
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides
