2-Amino-3-methylpyrazine

95-58-9

19838-08-5

The general procedure for the synthesis of 2-amino-3-methylpyrazine from 2-chloro-3-methylpyrazine was as follows: a mixture of 2-chloro-3-methylpyrazine (7 g, 54.69 mmol) and 25% ammonia (100 mL) was placed in a sealed tube, heated to 160 °C and reacted for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and subsequently concentrated under reduced pressure to give 2.18 g (89% yield) of 3-methylpyrazin-2-amine as a yellow solid. m/z 110 ([M+H]+) by LCMS.