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Isobutaneboronic acid

Basic information Description Reference Safety Related Supplier
Isobutaneboronic acid Basic information
Isobutaneboronic acid Chemical Properties
  • Melting point:108-111 °C(lit.)
  • Boiling point:180.0±23.0 °C(Predicted)
  • Density 0.910±0.06 g/cm3(Predicted)
  • storage temp.  0-6°C
  • pka10.49±0.43(Predicted)
  • form Crystalline Powder or Flakes
  • color White to cream
  • CAS DataBase Reference84110-40-7(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 37/39-26
  • WGK Germany 3
  • Hazard Note Irritant
  • TSCA No
  • HazardClass IRRITANT
  • HS Code 29319090
MSDS
Isobutaneboronic acid Usage And Synthesis
  • DescriptionIsobutaneboronic acid is also known as isobutylboronic acid. Isobutaneboronic acid has been used to synthesize potent and selective dipeptidyl boronic acid proteasome inhibitors, which are promising therapeutics to treat cancer and inflammatory diseases.1
  • ReferenceJ. Adams, M. Behnke, S. Chen, A. A. Cruickshank, L. R. Dick, L. Grenier, J. M. Klunder, Y. Ma, L. Plamondon, R. L. Stein, Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids, Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, pp. 333-338
  • Chemical Propertieswhite flake
  • Usessuzuki reaction
  • Uses2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.
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