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Isobutaneboronic acid

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Isobutaneboronic acid Basic information
Isobutaneboronic acid Chemical Properties
  • Melting point:108-111 °C(lit.)
  • Boiling point:180.0±23.0 °C(Predicted)
  • Density 0.910±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • form Crystalline Powder or Flakes
  • pka10.49±0.43(Predicted)
  • color White to cream
  • CAS DataBase Reference84110-40-7(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 37/39-26
  • WGK Germany 3
  • Hazard Note Irritant
  • TSCA No
  • HazardClass IRRITANT
  • HS Code 29319090
Isobutaneboronic acid Usage And Synthesis
  • DescriptionIsobutaneboronic acid is also known as isobutylboronic acid. Isobutaneboronic acid has been used to synthesize potent and selective dipeptidyl boronic acid proteasome inhibitors, which are promising therapeutics to treat cancer and inflammatory diseases.1
  • ReferenceJ. Adams, M. Behnke, S. Chen, A. A. Cruickshank, L. R. Dick, L. Grenier, J. M. Klunder, Y. Ma, L. Plamondon, R. L. Stein, Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids, Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, pp. 333-338
  • Chemical Propertieswhite flake
  • Usessuzuki reaction
  • Uses2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.
  • Uses
    (2-Methylpropyl)boronic acid can be used as:???
    • A reactant in the preparation of 4-isobutylisoquinoline from 4-bromoisoquinoline by Suzuki-Miyaura type couple reaction.
    • ?A catalyst along with aluminum hydroxide, boric acid in the polymerization of styrene.

    It can also be used as a reactant in:????
    • Copper catalyzed cross-coupling reactions.??????
    • The synthesis of polyborylalkanes by Ir-catalyzed C-H borylation reaction.????????
    • The preparation of heterosubstituted diazaboroles and borinines.

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