Basic information Description Chemical Properties Biological Functions Uses Preparation References Safety Related Supplier
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Sarcosine

Basic information Description Chemical Properties Biological Functions Uses Preparation References Safety Related Supplier
Sarcosine Basic information
Sarcosine Chemical Properties
  • Melting point:208-212 °C (dec.)(lit.)
  • Boiling point:165.17°C (rough estimate)
  • Density 1.1948 (rough estimate)
  • refractive index 1.4368 (estimate)
  • Flash point:>100℃
  • storage temp. Store below +30°C.
  • solubility H2O: 1 M at 20 °C
  • pka2.21(at 25℃)
  • form Crystals or Powder
  • color Colorless or white to yellow
  • PH6.1 (100g/l, H2O, 20℃)
  • Water Solubility 1480 g/L (20 ºC)
  • Sensitive Hygroscopic
  • Merck 14,8373
  • BRN 1699442
  • CAS DataBase Reference107-97-1(CAS DataBase Reference)
  • NIST Chemistry ReferenceSarcosine(107-97-1)
  • EPA Substance Registry SystemSarcosine (107-97-1)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 24/25-36-26
  • WGK Germany 1
  • RTECS VQ2897000
  • 3
  • TSCA Yes
  • HS Code 29224995
MSDS
Sarcosine Usage And Synthesis
  • DescriptionSarcosine is the N-methyl derivative of glycine. It can be metabolized to the glycine through sarcosine dehydrogenase. It can be naturally found in many body tissues including muscles. In the laboratory, sarcosine could be synthesized through the reaction between chloroacetic acid and methylamine. Sarcosine is a potential interesting direction for the treatment of mental illness such as schizophrenia, possibly being related to its effect of increasing the glycine content in the brain, which increased the NMDA receptor activity. Sarcosine is also effective in the treatment of depression. Recent study has shown that sarcosine might be an important bio-marker for prostate cancer.
  • Chemical PropertiesSarcosine, also known as N-methylglycine, is ubiquitous in biological materials and is present in such foods as egg yolks, turkey, ham, vegetables, legumes, etc. It reduced the production of sebum and imperfections linked to hyperseborrhea, thereby refining skin texture. Sarcosine matifies skin perfecting treatments and treatments for oily skin.
    Sarcosine
    Sarcosine is a natural amino acid found in muscles and other body tissues. It is found naturally as an intermediate in the metabolism of choline to glycine. Sarcosine is a white and deliquescence crystalline power. It is sweet to the taste and dissolves in water. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications.
  • Biological FunctionsSarcosine reduces dihydrotestosterone (DHT) by inhibiting the enzyme 5 alphareductase. Sebum production is stimulated by androgens. 5 alpha-reductase metabolises testosterone in the skin into its more potent form dihydrotestosterone (DHT) that is responsible for the overproduction of sebum. As a result, sarcosine reduces shine, tightens and reduces pore size, evens tone and complexion.
  • Usessarcosine is an intermediate in the production glycine from dietary consumption of choline. It is used in making toothpastes and biodegradable surfactants. Sarcosine can be found in foods such as vegetables, ham, egg yolks, turkey and legumes. The normal concentrations of sarcosine in human serum and in human urine are 1.4 µM and 1.6 µM respectively.
    Sarcosine has been observed to improve treatment of the mental illness known as schizophrenia: 2 g per day consumption of sarcosine (in addition to antipsychotic drug therapy) results in significant additional reductions not only both positive and negative symptoms, but also general psychopathological and neurocognitive symptoms. Sarcosine is thought to work by increasing glycine concentrations in the brain which causes increased NMDA receptor activation. Interestingly, consumption of sarcosine also reduced depressive symptoms in patients with schizophrenia. A clinical study showed sarcosine to be significantly more effective in treating major depression than the established antidepressant drug Citalopram.
  • PreparationSarcosine is prepared by boiling creatine with an aqueous solution of IO times its weight of barium hydroxide until all odour of ammonia has disappeared. The creatine is decomposed into sarcosine and urea, the latter product being further split up into ammonia and carbonic acid.The excess of barium hydroxide is removed by a current of carbon dioxide, the liquid boiled, filtered, and evaporated to a syrup, from which the sarcosine is deposited in foliated crystals on standing. Sarcosine also results from the action of acids or alkalies on caffeine and theobromine (Vol.VI); and w. Paulmann (Arch. Pharm., 232, 601) recommends the hydrolysis of caffeine as the best method for the preparation of sarcosine, the yield being 60% of the theoretical.
  • Referenceshttps://en.wikipedia.org/wiki/Sarcosine
    https://pubchem.ncbi.nlm.nih.gov/compound/sarcosine#section=Top
  • Chemical PropertiesWhite crystalline powder
  • UsesHas been found in starfish and sea urchins. It is used as intermediate in the synthesis of antienzyme agents for toothpaste. Found to be a marker for prostate cancer bioagression.
  • UsesSarcosine can improve people's intelligence, especially for exams such as the students need to temporarily increase the effectiveness of intelligence is more obvious. sarcosine can increase muscle strength and anaerobic explosiveness.To prevent damage caused by the brain injury. Sarcosine can effectively improve athletic performance,power, and shorten muscle recovery time.
  • Usessarcosine is a naturally occurring amino acid that is used in cosmetic formulations as a skin conditioner. There are some studies indicating that it is effective for oily skin. Its chemical name is n-methyl glycine.
  • DefinitionChEBI: A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine.
  • General DescriptionDeliquescent crystals or powder. Has a sweetish taste.
  • Air & Water ReactionsDeliquescent. Water soluble.
  • Reactivity ProfileSarcosine is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Sarcosine is incompatible with acids. .
  • Fire HazardFlash point data for Sarcosine are not available. Sarcosine is probably combustible.
  • Biological ActivityEndogenous inhibitor of GlyT1 that displays antipsychotic activity. Potentiates the action of glycine on the NMDA glycine binding site.
  • Purification MethodsCrystallise sarcosine from absolute EtOH, 95% EtOH or H2O. It sublimes at 180-185o/0.3mm with 99.1% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cocker & Harris J Chem Soc 1291 1940, Cocker & Lapworth J Chem Soc 1897 1931, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2750 1961, Beilstein 4 III 1121, 4 IV 2363.]
Sarcosine Preparation Products And Raw materials
Sarcosine(107-97-1)Related Product Information
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