CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.
Biochem/physiol Actions
CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.