146422-58-4

mAChR

CDD0102 (CDD-0102) is an efficacious muscarinic agonist in cell lines expressing M ₁ receptors. CDD0102 displays much lower activity at M ₃ and M ₅ receptors.

After i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. In toxicological studies, the LD ₅₀ of CDD0102 is 190 mg/kg following i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, after oral administration at a dose of 10 mg/kg, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration. Again, no side effects are observed at this dose.