160756-38-7
![160756-38-7 结构式](https://img.chemicalbook.com/CAS/20211123/GIF/160756-38-7.gif)
160756-38-7 用途与合成方法
NMDA receptor/ion channel
CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [ 3 H] MK-801 binding with a K i of 1.8 nM in synaptosomal membrane preparations from rat brain.
In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED 80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats.