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Acacetin

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Acacetin Basic information
Acacetin Chemical Properties
  • Melting point:260-265 °C(lit.)
  • Boiling point:346.76°C (rough estimate)
  • Density 1.2160 (rough estimate)
  • refractive index 1.6200 (estimate)
  • storage temp. 2-8°C
  • pka6.51±0.40(Predicted)
  • λmax335nm(EtOH)(lit.)
  • Merck 14,13
  • BRN 277879
  • InChIKeyDANYIYRPLHHOCZ-UHFFFAOYSA-N
  • CAS DataBase Reference480-44-4(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS DJ3002000
  • 3-8-10
  • HS Code 29329990
MSDS
Acacetin Usage And Synthesis
  • Chemical PropertiesYellow Solid
  • UsesVEGF expression inhibitor and tumor angiogenesis. A flavonoid with antiaggregatory activity in human blood.
  • DefinitionChEBI: A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
  • Enzyme inhibitorThis naturally occurring flavone (FW = 286.27 g/mol; CAS 480-44-4), also known as 5,7-dihydroxy-4’-methoxyflavone and 7-O-methylapigenin, and systematically named as 5,7-dihydroxy-2-(4-methoxyphenyl)-chromen-4- one, from the black locust Robinia pseudoacacia is the aglycon of linarin and acaciin and is biosynthesized by apigenin 4'-O-methyltransferase from S-adenosyl-methionine and 5,7,4’-trihydroxyflavone (apigenin), yielding Sadenosylhomocysteine and acacetin. The chemical synthesis of acacetin was accomplished by Robert Robinson, who was awarded the 1947 Nobel Prize in Chemistry for his work on alkaloids and organic synthesis. Target(s): glutathione S-transferase; xanthine oxidase, Ki = 0.11 μM; CYP1A; CYP1B1; glutathione-disulfide reductase; DNA topoisomerase I; [myosin light-chain] kinase; and protein-tyrosine kinase, or non-specific protein-tyrosine kinase.
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