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Capmatinib

Basic information MET small molecule inhibitor Originator Safety Related Supplier
Capmatinib Basic information
Capmatinib Chemical Properties
  • Density 1.40
  • pka13.82±0.46(Predicted)
Capmatinib Usage And Synthesis
  • MET small molecule inhibitorCapmatinib(Synonyms: INC280; INCB28060) is a competitive inhibitor with very potent and selective activity against MET compared to other kinases. It has been shown in vitro that cell lines made resistant to erlotinib, an EGFR inhibitor, could be resensitized after capmatinib treatment. Results from a phase Ib/II study of patients with EGFR-mutated, MET-dysregulated NSCLC have shown promising responses to a combination of capmatinib and gefitinib (EGFR TKI) following disease progression from an only EGFR TKI treatment regimen. Recommended phase II dose was determined to be capmatinib 400 mg twice/day and gefitinib 250 mg once/day. Most common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.
  • OriginatorNovartis
  • DescriptionCapmatinib is a competitive inhibitor with very potent and selective activity against MET compared to other kinases.
  • Side effectsMost common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.
  • in vitroIt has been shown in vitro that cell lines made resistant to erlotinib, an EGFR inhibitor, could be resensitized after capmatinib treatment. Results from a phase Ib/II study of patients with EGFR-mutated, MET-dysregulated NSCLC have shown promising responses to a combination of capmatinib and gefitinib (EGFR TKI) following disease progression from an only EGFR TKI treatment regimen. Recommended phase II dose was determined to be capmatinib 400 mg twice/day and gefitinib 250 mg once/day.
Capmatinib(1029712-80-8)Related Product Information
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