Peginterferon alfa-2b

Treatment of chronic hepatitis B and C infection with or without ribavirin

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: inhibits metabolism of aminophylline and theophylline (enhanced effect).
Antivirals: use adefovir with caution; increased risk of peripheral neuropathy with telbivudine.
Immunosuppressants: (e.g. ciclosporin, tacrolimus, sirolimus) may have an antagonistic effect.

The metabolism is not known. Clearance is via the kidneys.