TRIPHENYLPHOSPHINE RESIN

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Polymer-bound triphenylphosphine is a solid-supported reagent that can be used as a better alternative to triphenylphosphine in the Mitsunobu reaction.
It can also be used:

• For the esterification of alkylphosphonic acids using primary alcohols in the presence of iodine and imidazole.
• To catalyze the conversion of 3-[3-(1,3-dioxolan-2-yl)-1-hydroxypropyl]pyridine to 3-[1-bromo-3-(1,3-dioxolan-2-yl)propyl]pyridine using carbon tetrabromide.
• To isomerize (Z)-nitro olefins to the (E)-isomers.
• To prepare polymer-bound ylides which are useful in Wittig reactions.
• To convert alcohols or carboxylic acids to the corresponding chlorides.
• In combination with carbon tetrachloride for the coupling N-alkoxycarbonyl α-amino acids and primary amines to form the corresponding amides.

Triphenylphosphine resin is used for the preparation of polymer bound ylids which are useful for Wittig reactions.

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reaction type: solution phase peptide synthesis
reagent type: ligand