雌马酚
雌马酚 性质
| 熔点 | 158-160?C |
|---|---|
| 沸点 | 441.7±45.0 °C(Predicted) |
| 密度 | 1.286±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 溶于乙醇 |
| 形态 | 结晶粉末 |
| 酸度系数(pKa) | 9.94±0.40(Predicted) |
| 颜色 | 白色至浅黄色至浅红色 |
| 水溶解性 | Soluble in DMSO and methanol or 100% ethanol. Insoluble in water. |
| 敏感性 | Hygroscopic |
| BRN | 87752 |
| InChI | InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2 |
| InChIKey | ADFCQWZHKCXPAJ-UHFFFAOYSA-N |
| SMILES | C1OC2=CC(O)=CC=C2CC1C1=CC=C(O)C=C1 |
雌马酚 用途与合成方法
Equol is first isolated and identified from pregnant-mares' urine and later found in the urine of the goat, cow, hen and sheep. Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers. S-equol is the exclusive product of human intestinal bacterial synthesis from soy isoflavones and both enantiomers are bioavailable. S-equol has a high affinity for estrogen receptor beta (K i =0.73 nM), whereas R-equol is relatively inactive. Equol could promote the proliferation and differentiation of rat osteoblasts through activating the ER-PKCα-related signaling pathway. The alkaline phosphatase activity also increases significantly in all of the equol and 17β-estradiol (E2 ) groups. Equol also significantly elevates the osteocalcin levels.
Equol is a modest natriuretic and vasorelaxant agent in the rat. Orally administered equol is about 8-fold less potent than orally administered furosemide. In isolated aortic rings precontracted by administration of phenylephrine, administration of equol relaxes the contracted aorta (concentration for half-maximal activity 58.9±16 μM). Equol possesses anticancer activity that suppresses tumor formation via apoptosis induction in rats with DMBA-induced mammary gland tumors. In addition, equol shows a hepatic protective effect by acting as an antioxidant and by reducing apoptosis.
