Bromoform is a colorless (turns yellow onexposure to air) with a sweet-smelling, chloroform-likeodor. Odor threshold=0.447 ppm. Molecular weight =252.8; Specific gravity (H2O:1)=2.9; Boiling point =149.5 ℃; Freezing/Melting point=8.3 ℃ (to hexagonalcrystals); Vapor pressure=5 mmHg at 20 ℃. HazardIdentification (based on NFPA-704 M Rating System):Health 2, Flammability 0, Reactivity 0. Soluble in water;solubility=0.1% at 20 ℃.
Bromoform is a colorless to pale yellow liquid with a high refractive index, very high density, and sweetish odor is similar to that of chloroform. It is slightly soluble in water and is nonflammable. Bromoform can form in drinking water as a by-product from the reaction of chlorine with dissolved organic matter and bromide ions.
Clear, colorless to yellow liquid with a chloroform-like odor. Odor threshold concentration in
water is 0.3 mg/kg (Verschueren, 1982).
Bromoform is a colorless to yellow liquid with a density about
three times that of water. It has an odor and sweetish taste
similar to chloroform and is not combustible. It has been used
as a degreasing solvent, in chemical synthesis, and in fire
extinguishers, and is no longer used as a sedative for children
with whooping cough. Currently, bromoform is produced only
in small amounts for use in laboratories and in geological and
electronics testing.
ChEBI: Bromoform is a member of bromomethanes and a bromohydrocarbon.
In separating mixtures of minerals. Bromoform is used as a fluid for mineral ore separation in geological tests, as a laboratory reagent, and in the electronics industry in quality assurance programs.
Bromoform was formerly used as a solvent for waxes, greases, and oils, as an ingredient in fire-resistant chemicals and in fluid gauges. It was also used in the early part of this century as a medicine to help children with whooping cough get to sleep. Currently, bromoform is only produced in small amounts for use in laboratories and in geological and electronics testing.
Bromoform can be prepared by reacting chloroform (see IAC, 1987) with aluminium tribromide at less th an or equal to 60°C; by reacting ethanol with sodium hypobromite; or by the redistribution reaction between chloroform and ethyl bromide (Harlow & Ross, 1932; Soroos & Hinkamp, 1945; Sherman & Kavasmaneck, 1980).
Bromoform appears as a colorless liquid with a chloroform-like odor. Denser than water (density: 2.9 g / cm3 ) and slightly soluble in water. Hence sinks in water. Nonflammable. Toxic by ingestion, inhalation and skin absorption. A lachrymator. Used as a solvent and to make pharmaceuticals. Often stabilized with 1 to 3% ethanol.
Slightly soluble in water.
Heating Bromoform to decomposition produces highly toxic fumes of carbon oxybromide (carbonyl bromide) and hydrogen bromide [Sax, 9th ed., 1996, p. 519]. Reaction with powdered potassium or sodium hydroxide, Li or Na/K alloys, is violently exothermic [Weizmann, C. et al., J. Am Chem. Soc., 1948, 70, p. 1189]. Explosive reaction with crown ethers in the presence of potassium hydroxide [Le Goaller, R. et al., Synth. Comm., 1982, 12, p. 1163].
A questionable carcinogen. By ingestion,
inhalation, and skin absorption. Liver damage, eye
and upper respiratory tract irritant.
Probable routes of human exposure to bromoform are inhalation, ingestion, and dermal contact.
Harmful if inhaled, swallowed, contacts skin or eyes or is absorbed through skin. It is a lachrymator, respiratory irritant, a narcotic and an hepatotoxin. Prolonged exposure may cause dermatitis. Inhalation causes irritation of nose and throat; provokes the flow of tears and saliva and reddening of the face. Ingestion may cause dizziness, disorientation and slurred speech, unconsciousness and death.
Non-Cancer: Bromoform is a central nervous system depressant, and its vapors are highly irritating to the eyes and respiratory tract. Limited observations in humans and animal studies indicate that acute inhalation or oral exposure to high levels of bromoform may cause liver and kidney injury. Chronic effects of bromoform exposure in humans have not been studied, although animal studies indicate adverse effects on the liver, kidney, and central nervous system (U.S. EPA, 1994a).
Behavior in Fire: May decompose to produce toxic gases and vapor such as hydrogen bromide and bromine.
Suspected carcinogen
with experimental neoplastigenic data. A
human poison by ingestion. Moderately
toxic by intraperitoneal and subcutaneous
routes. Human mutation data reported. A
lachrymator. It can damage the liver to a
serious degree and cause death. It has
anesthetic properties simdar to those of
chloroform, but is not sufficiently volatile
for inhalation purposes and is far too toxic
for human use. As a sedative and antitussive
its medicinal application has resulted in
numerous poisonings. Inhalation of small
amounts causes irritation, provoking the
flow of tears and saliva, and reddening of
the face. Abuse can lead to adhction and
serious consequences. Explosive reaction
with crown ethers or potassium hydroxide.
Violent reaction with acetone or bases.
Incompatible with Li or NaK alloys. When heated to decomposition it emits hghly
toxic fumes of Br-. See also BROMIDES.
Tumorigen,Drug, Mutagen; Reproductive Effector; Human Data. Bromoform is used in pharmaceutical manufacturing; as aningredient in fire-resistant chemicals and gauge fluids; andas a solvent for waxes, greases, and oils.
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Biological. Bromoform showed significant degradation with gradual adaptation in a staticculture
flask-screening test (settled domestic wastewater inoculum) conducted at 25 °C. At
concentrations of 5 and 10 mg/L, percent losses after 4 wk of incubation were 48 and 35,
respectively (Tabak et al., 1981).
Surface Water. Kaczmar et al. (1984) estimated the volatilization half-life of bromoform from
rivers and streams to be 65.6 d.
Chemical/Physical. The estimated hydrolysis half-life in water at 25 °C and pH 7 is 686 yr
(Mabey and Mill, 1978). Products of hydrolysis include carbon monoxide and hydrobromic acid
(Kollig, 1993). When an aqueous solution containing bromoform was purged with hydrogen for
24 h, only 5% of the bromoform reacted to form methane and minor traces of ethane. In the
presence of colloidal platinum catalyst, the reaction proceeded at a much faster rate forming the
same end products (Wang et al., 1988). In an earlier study, water containing 2,000 ng/μL of
bromoform and colloidal platinum catalyst was irradiated with UV light. After 20 h, about 50% of
the bromoform had reacted. A duplicate experiment was performed but the concentration of
bromoform was increased to 3,000 ng/μL and 0.1 g zinc was added. After 14 h, only 0.1 ng/μL
bromoform remained. Anticipated transformation products include methane and bromide ions
(Wang and Tan, 1988).
At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the adsorption capacities of the
GAC used were 19.6, 5.9, 1.8, and 0.52 mg/g, respectively (Dobbs and Cohen, 1980).
Color Code—Green: General storage may be used.Prior to working with this chemical you should be trainedon its proper handling and storage. Bromoform must bestored to avoid contact with incompatible materials listedabove. Store in tightly closed containers in a cool well-ventilated area away from heat and light.
Bromoform requires a label of “POISONOUS/TOXIC MATERIALS.” It falls in Hazard Class 6.1 andPacking Group III.
The storage and stability of bromoform and chloroform are similar. Ethanol, added as a stabilizer, is removed by washing with H2O or with saturated CaCl2 solution, and the CHBr3, after drying with CaCl2 or K2CO3, is fractionally distilled. Prior to distillation, CHBr3 has also been washed with conc H2SO4 until the acid layer is no longer coloured, then dilute NaOH or NaHCO3, and H2O. A further purification step is fractional crystallisation by partial freezing. [Beilstein 1 IV 82.]
Bromoform is not found as a liquid in the environment
because it is expected to volatilize from dry soil surfaces due
to its vapor pressure of 5.40mmHg at 25 °C. It is also
expected to volatilize from moist or wet surfaces because
Henry’s law constant is 5.4×10-4 atmm3 mol-1. Bromoform
is expected to have high mobility in soil due to its Koc
value of ～120. This low Koc value implies that bromoform
will have only a little tendency to adsorb to soil or sediment
from water sources. Bromoform does not hydrolyze in
water. Bromoform undergoes limited biodegradation under
aerobic conditions but is readily biodegraded in the presence
of methane-producing bacteria under anaerobic conditions.
Bromoform exhibits a low bioconcentration factor
of 14, and little bioconcentration in aquatic organisms is
expected.
Heat causes bromoform to decomposeforming toxic and corrosive hydrogen bromide and bromine.Bromoform is a weak acid. Reacts violently with oxidants,bases in powdered form. Reacts with chemicallyactive metals (alkaline metals), powdered aluminum, potassium, sodium, zinc, and magnesium and acetone under basicconditions, causing fire and explosion hazard. Attacks someforms of plastic, rubber, and coating. Corrosive to mostmetals.
The cancer risk-based screening levels for bromoform were established on 9/22/92. They are as
follows:
IRSL = 0.9 μg/m3, annual averaging time;
SRSL = 9 μg/m3, annual averaging time.
